??????????2025????????????????????2?????????21????????????????????????????,??????«?????????????????????????????????????»????????????“Base-modified nucleotides mediate immune signaling in bacteria(??????????????????)”?????????(??)??????????,????“?????????”(Kongming),???????“??”???????,?????

??????????????????,???????,??“????”???????????????????1950?????????(????cAMP?cGMP)???,????????????????????,??????????????????,?????????,????????????????,?KomA(??A)?KomB(?B)?KomC(?????????????C)?????????????,??(DNK)?“???”:KomA??DNK?????????????????????,?????????????(dAMP)?dITP???KomC????NAD⁺,???????????“??”?????????????,???????????????????????,????“???????????”???,??????“??????????”???????,???

?????????????,“????????????”????????????????????,???????????(????KomB-KomC?????????????????KomA)??????????????????,?dITP??:?????,??????(???ADA?????????????????)????????????,???

(??? ????????????????? ?????) ???:?????

??

??:???????????,??????????,??????????????