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??????,???????????????????????,???????????????????????“????????????????????”???????????1950????(??????????cAMP?cGMP)??????????????????,????????????????????????,??????????,??????????????????????,??,??KomA(??A)?KomB(????B)?KomC(?????????????????C)??????????????,??(DNK)?????????“????”:KomA?DNK??????,?(dAMP)????dITP???KomC????NAD⁺,?????????????“??”????????,????,??????“??????????????????”????,????“????????????”????????????,????

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