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??2025??2???????21????????????????????????????,?«??????»????“Base-modified nucleotides mediate immune signaling in bacteria(??)”?????????????????(?????????)?,??????????“????????????????”(Kongming),??????????????????“????????????????????”??????,???????

?????????????,????????,???????????“?”?????1950??????(????cAMP?cGMP)??,?????????????????????????,??????????????,???????,?????,?KomA(??A)?KomB(?????????B)?KomC(?????????????????????C)?????????????????,?????????????(DNK)???“?????????????”:KomA??????DNK????????????,???(dAMP)?????????????????dITP???KomC??????????????????NAD⁺,??“???????”????????,????,??“??”?????????????????????????????????????,???????“??”??,??

??????,“???????????????”???????????????????????,?????????????????(?????KomB-KomC??????????????????KomA)????????????????????????????,????????????dITP??????:??,???(??ADA?????????????????)???????????,?????

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