??????????????

?????????????????2025??????2????21???????????,??????«?????????????»????????????????????“Base-modified nucleotides mediate immune signaling in bacteria(??????????????????)”????????(?)?,?????????“??????????????????”(Kongming),???????????“??????”?????,???

????,?????????????????????,???????????????“????”??????????????1950??????????(????cAMP?cGMP)???????,????????????????????????????????????????,??????????,???????????????,?????????,???KomA(??????A)?KomB(????B)?KomC(????C)?????????????????????,??????????(DNK)?????????????????“??”:KomA??????DNK??,???????????????????????(dAMP)????????????????????????????dITP?????????????????????KomC?NAD⁺,???????????“??”??????????????,???,?“??????????”??,??“??????????????????”???????????????????,???

??,“?????????????????????”????,????????????(?????KomB-KomC?????????KomA)??????????????,????????????dITP???:???????,??(????ADA??)??????,?????

(??????? ?????? ??) ?????:???