??????????????
??
?????????2025???????2?????????????????21????????????,??????«?»??????????“Base-modified nucleotides mediate immune signaling in bacteria(?????????????)”??????????????????(????????????)??????????????????,?????????“??????”(Kongming),??“????”????,????
???,??????????????????????,?????????“??????”??????????????????????????????????????1950???????????(????cAMP?cGMP)??????????,???????????,????????,?????????????????,????????????,??????KomA(??????A)?KomB(???????????B)?KomC(???C)???????,????????????????(DNK)????“??????????????????”:KomA??DNK??,??(dAMP)????dITP???KomC???????NAD⁺,??“???”???????????????????????????????,?????????????????????,???????????“????”?,???“???????????????????????”?????,?????
??????????????????,“?”?,??????????????????(??????KomB-KomC????????????????????????????KomA)?????????????????,??????dITP??:?,?????????????(?????????????????ADA?)??,?????
(???????????????????? ??????? ??) ???:???
?????????
????????????????????????????????
????
- 1?????2??7??????????
- 2???????????????????
- 3???????????????:????
- 4??:????????????????????
- 5?????????????
- 6???????????!????????
- 7????-?????????????16?
- 8???????????????:????
- 9?????????????????????
- 10?????????:??????1.5%??????…
- 11???-???2???????4-1????
- 12?????????????????????
- 13???:??5?????????6000???
- 14??????????“???”?????????
- 15????-?????????????16?
- 16??????????37?????1.03??
- 17409????!32??????????????
- 18??????????????????????
- 19??????:??????????????
- 20?????????????????????