??????????????

??2025????????????????????2???21?????????????,?????????«?»???????????????“Base-modified nucleotides mediate immune signaling in bacteria(??)”????(??????????)????????????????,??“??”(Kongming),?????????????????“??????????”???,?????

????,??????????????????????????????,??“?”?????1950??????(?????????????????????????????????????cAMP?cGMP)???????????,???????????????????????,???????,?????????????????????????,?????????,??????????KomA(??????A)?KomB(?????????????B)?KomC(?C)???????????????????????,?????????????(DNK)????????????????????????????“?”:KomA????DNK?????????,?????????????????????(dAMP)????dITP?????KomC????NAD⁺,???????“?????????????????”???????????????????????????????????,?,????????????“??????”??????,??“????????????”??????,?????????????

??????,“???”??,???(??????????????????KomB-KomC??KomA)???????????????????????,?????dITP??????:??,???????????(????ADA???)??????,???

(?????? ??????? ??????) ???:??