??2025???2?????????21??????????????????,??????«?????????????????»???????“Base-modified nucleotides mediate immune signaling in bacteria(????)”???????????????(????????????????????????????)????,????“???”(Kongming),????????????????????“????”???,????????????????????????

??,??????????????????????????????????,?“??????”???????1950?(????cAMP?cGMP)?????????????????,???????????????,???????????,????????,????????????,?KomA(??????A)?KomB(????????????????B)?KomC(???????????C)?????,?????????????????(DNK)??“?????????????”:KomA????DNK??????????????????,??????????(dAMP)??????dITP???KomC???????????NAD⁺,??“???”????,????,????“??????”??,?“?????”????????????,????

??????????????????,“??????????”??,?????????(??KomB-KomC?????KomA)??????????????????????????,???????dITP???????:??????,???????????????(????????????????????ADA????)???????????,??????????????????????????????????????

(????????? ?????????????????? ??) ???:???

??

??:???????????,??????????,??????????????