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????????????????????????????2025???2???????????????????????21????????????????,????«??????»??????????????????“Base-modified nucleotides mediate immune signaling in bacteria(?????)”?????????????????(???)??,???????“??????????”(Kongming),??????????????????“??”??????????????????,??

??????,?????????????,????“??”????1950????????????(?????????????????cAMP?cGMP)???????????,??????????????????,??????????????????,??????????????????????,?????,??????????KomA(???A)?KomB(????B)?KomC(??C)?????????,????(DNK)?????????“??”:KomA??DNK????,?(dAMP)??????dITP?????????????????????KomC???????????NAD⁺,???????????“?????????????????”????????????,??????,????????????“????????????”??????,??????????????????“??”???????,??????????????????????????????????????

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