??????2025????2??21??????????????????,????«????????????????»??“Base-modified nucleotides mediate immune signaling in bacteria(????)”????????(?????????)???,????“?”(Kongming),???????“?????????????”??,???
??????,??????????????,??“?????????”??1950???????????????(???????????cAMP?cGMP)??????????,??????????????,?????,???????????,??,????????????KomA(????A)?KomB(???B)?KomC(???????????C)????????,??????(DNK)?????????????????“???????”:KomA??DNK????????????????????,?????????????(dAMP)?????????????????????dITP????KomC?NAD⁺,??????“??????????”???????,??????????????????,??????????????????“?????????????????”??????????????????,??????“???”??????????????,??????????????????????????????????????
?????,“????????????????????”????????????,???????????????????????(?KomB-KomC?????????KomA)????????????????????????,??dITP????:??????????,??(????????????????????????????ADA???????)????,????
(????? ???? ????) ?????????????:??
??:??????????????
???????3??????????????
???100???7????5???????
????:???????????????
????!?????????????????
????!?????????????????
????23?????????????
????????????2018???????]
?????????????????:????
??:?????????????????
?????:???????????????
?????????????????????
?????????????????????
?????:???????????????
???????????????????????
??:??????????????
??!????????“????”BBC????
??:????PK?????????85???
?????????????????
????????3????????1???
?????????????????????
??!???????????????????
«????»????????????
??CEO????13???????????
?????????????????????