??????????????

????:?????????:??????????

????2025??2????21???????,??????????«??????????????????»????????????“Base-modified nucleotides mediate immune signaling in bacteria(???)”???????????????????????(??????????????????)?,??????????????????“????????????????????”(Kongming),???“???”??,???

??????,?????????,?????????????“??”???????????1950??(??cAMP?cGMP)???,??????????????????,??????????????,??????????????????????????????????,???????????,????KomA(?????????????A)?KomB(???????????????????????B)?KomC(????C)????????,????(DNK)??“??”:KomA?????????????????????????????????????DNK?,??????(dAMP)???????????dITP??????????KomC??NAD⁺,??????????“??????”????????????????,??????,??“?????????”????????????,??????“????????????????????”??????????????????????,????????????????

?????????,“????????????”?,?????????????????(?????????????????KomB-KomC??KomA)?????????,???????dITP??????:?,???????(??????ADA?????)?????????????????,???

(???? ??? ?????????????) ??:?????