????:1?500?3????????:?????????

2?????????

3???sn??

4???????

5????????????

???2???????????????10??????? (???????? ????)??????????????(????)???10??,?????????(????????????????)?(????),??????????????????(?APL)????

????????? ??

?????????????????????,???????????????APL??????????????,???????,???????????????????97%,?????????

?????????,??,?????APL???,???????????????????????

??????????,?????????????????????????(FDA)???(EMA)?????,????????FDA????????????????????????????????????????,?????????????????

??????????????????????????,??,?,??????APL??????????,??????(??????????)

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