?? ????????????20.2% ???????????????13.7%
????:1???????:?????????
2?????????
3?????
4???????ktv
5?????
?????????????12???????5???? ??????????,???????????????3b???????????SURMOUNT-5???????????????????????????topline???????????????????????????????????,?????????????????(tirzepatide)??????(semaglutide)???????????????????????,?1.47????????????
????????,??????20.2%,?????????????????????13.7%i???72?????????????????,????????????????,????????5????????????????,???
????, ????,???????????????GIP????????????GLP-1????GIP??????GLP-1?????????????????????????(CKD)????????(MMO)??????????????????????????,?(FDA)??????????????????(OSA)??????????????????????????????????????????????(FDA)?????????????????????????(HFpEF)????
????????2022?5????????????????????13????????????(FDA)??,??2?????????????????;2023????????????11??????8??????,FDA??????????????????(BMI=30kg/m2)?????????????(BMI=27kg/m2)?????????????????????????????????
???????????GIP(?)???GLP-1(???????-1)??????????????????????????,???
“????????????,???????????????????????,???????????????,”????????????Leonard C. Glass?????,“???????????????,??,???????????????????????????????????????,?????????1.47?????????????FDA?????GIP/GLP-1????,??”
?:“???????????????????,??????,??????????????????”
?,???,??????????31.6%?????????25%,??????????????????16.1%?????
??SURMOUNT-5???,????????SURMOUNT????????????????????????????,????
????SURMOUNT-5????????????????????????????,??????????
???????????????,SURMOUNT-5(NCT05822830) ????????????????????3b ????????????????????,????????????????????(??????????????????????????????)??,??????????????(tirzepatide)??????????????(semaglutide)?????????????751?,?1:1??,???????(10mg?????15mg)????????????????????????(1.7mg?2.4mg)?????????????????????????72??,???
i???????????????????????(treatment-regimen estimand)??,?????,??????????????????????????????????(??????????????????????)???,?????,??????????????? ??????????:???