????:2024-12-06 10:40:54 ??:????
????:?????????????:????????????
??12??????5?????? ??????,????3b????SURMOUNT-5???????????????topline???????????????????????,???????????????(tirzepatide)???????????????(semaglutide)????????????????????????,??????1.47??????????????????????????
??,????20.2%,????????????????13.7%i???????????72???????????????????????????,?????,????????????5???,???
???, ?????????,???????GIP?GLP-1???????????GIP??????????????????GLP-1????????????????????????????????????????(CKD)???(MMO)?????????????????????????,?????????????????????(FDA)???????????????????????(OSA)????????(FDA)????????????????????(HFpEF)???
????????????????????????????2022???????????5?13????????(FDA)???????????????????????,????2???????;2023?11????8???????????????????????,FDA??????(BMI=30kg/m2)???????????????(BMI=27kg/m2)???
????GIP(?)??????????????GLP-1(?????????????-1)?????????????????????,??????????
“???????,??????????????,??????????????????,”??Leonard C. Glass????????,“?????????,????????????????????,??????????????????,?????1.47???????????????????????????????????FDA????????????????????????????????GIP/GLP-1?????,?????????????????”
???:“????????????????????????????????????????????,??,???????????”
???,??,????31.6%????25%,????????????16.1%???????
?SURMOUNT-5???????????????,??????SURMOUNT??????????????????????,???????
?????SURMOUNT-5???????,?????????????????????????????????????
????????,SURMOUNT-5(NCT05822830) ?????????3b ????????????????,?(????????????????????????????????????????????????)????????,?????????????????(tirzepatide)??????????????(semaglutide)?????????????????751????????????,???1:1???????????????????,????????(10mg??????????15mg)?????????(1.7mg?????2.4mg)?????????????72??,??
i?????????????(treatment-regimen estimand)????,??,??????????????????????(??????????????????????????????????)???????????????????????,?????,???????????? ???:???????
????