?? > ???? > ??

????????????20.2% ???????????????13.7%

????:2024-12-06 09:44:04 ??:????

????:?????200????:?????????

?????12???????????????5???????????? ???,??????3b????????????SURMOUNT-5??????topline????????????????????????,??????(tirzepatide)????(semaglutide)?????,????1.47?????????????????????

?,??????20.2%,???????13.7%i??????????????72????,???????????????,????????5??????????,?????????????????????????

???, ???,??????????????????GIP??GLP-1?????????????????????????????GIP???????????GLP-1??????????????????(CKD)???????????(MMO)???????????,???????????????????????(FDA)??(OSA)??????????????????(FDA)??????????????(HFpEF)????????????????

??2022?????????5??13?(FDA)???????????????????????,???????????????2????;2023??????11?????8???,FDA??????????????????????(BMI=30kg/m2)????????????????????????????????(BMI=27kg/m2)???

??GIP(??)??????????????????????????????????GLP-1(?????????????????-1)???????????????????,?????????????

“????,?????????????????,???????????????????????,”?????????????????Leonard C. Glass???,“???????????????????????????,???????,????,???????????????????????1.47???????????????????????????FDA???????????????GIP/GLP-1???????????,??”

???:“?????????,????????????????,????????????????”

?,???????,?????????31.6%?????????25%,??????????16.1%?????

???????????????SURMOUNT-5???,?????????????SURMOUNT??????????????????????,??????????????

?????SURMOUNT-5???????????,???????????????????????

????????????????,SURMOUNT-5(NCT05822830) ????????????????????????????3b ?????,??(?????????????????????????????????)?,??????????(tirzepatide)?????????(semaglutide)????????????????????????????????????????751?,???????????????1:1??????????????????????,????(10mg????????15mg)??????????????(1.7mg????????????????????2.4mg)????????72??,???????????????

i??(treatment-regimen estimand)??,??????????????????,????????(?????????????????????????????)??????????????????????????,????,??????????? ??:????????????????????

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