??? “?????????????”????

????:??????:?????150??

??????????????????9?30?????????(??????????????????? ??? ??? ? ???)?????,?????????????????????,???????????,??,??????????????????700???

????????,A??????:?????????,??,??????;???????????,?????????????????????,??,??????;??,?????“??????????????”?

??

??????????,??9??????????,??????18???

??????????

9??????????????23?,????????,??????????????????????????,????????,??,??????????????

?????,????????????????,?????????????????4?????,???????????9?????????,??

???????????,???????????????????????????,9????????????????14????,?,???,????????????????????????????3??????,????????,????????????9?????7???????????????,????????????,??????

  ?????????????????,???????9????????,???????????????18???(???????????????????:? ??????????????? ????????????????????????)

??

???????????,????????????????????????,?????????????????????

??,????????,???ADC?mRNA?????,??????????2024??,?????????????????????,??27.71%,??????? ??????????????65.87%,?277.60%?

?,???????????9??“????”??????????,??,????????TSLP?OX40(CD134)???????????????(pDCs)?????????????,???????,??????????????????????????

???????????????????????9??13????,?????????,??????????????????????????????????????????????????????

??????????????????????????,??????????????????,?????????????????????2023??????????????????,????????????????2022??647?????????????2023?????????????562??,???????????13.14%?

?,???,?????????????,??????,??????????????????????,??2024?10%?????

“??”??

?,????????,????????“??”??,??????????,?????

9????25???,?????????????????????,?????,????????????????????,?????????????????????????,??????????????????????????,????????????????

?????,???????????????????????????????????,?1989?????,???(MIT)???????????????,?????????????????,3M??????????????????????????????????(3MUSA)????????????,???????

2017??????????????,??????????,?????????????????

???,?????????????,2023???,??????79.80???????????????????,??????????24.78%;????????12.58???????,??????????42.91%??????????????????2024?????????????,?????21.33%;??27.48%?

????“???????????”???????????9?????????????????20??????????????????????,??,?????????????????????,???????????????????

????,??1980?,??????????????,??????,??????????(?????????????????)?????????????????????????

??????????????,?????????????HPV????????????,???????????????HPV????????????????,????????????,??

??“?????”????????,???????????????,?????????,????,????????????????????????(???)

?????:????