??????????????????2025???????2??21?????????????,????«??????»????“Base-modified nucleotides mediate immune signaling in bacteria(?)”???????????????????????????(??)???????,??????????“????”(Kongming),?“????????????????????????????”??????????????????,??????????????

??,????????????????????????,?????????????????????????????????????“????????????”??????????????????1950?????????????????(??????cAMP?cGMP)??,???????????????,??????,???????????,??????,??????KomA(??????A)?KomB(????????????B)?KomC(?????????C)??????????????????????????,????????????????????(DNK)??????????????????“?”:KomA?????????DNK????????????,?(dAMP)???????????dITP?????KomC??????NAD⁺,????????????????“?????????????????”??????????????????????????,???,?“??????”?????????????,??“??????”?????,?????

??,“???”????,?????(?KomB-KomC??KomA)??????????????????????????,??dITP?????:??,??(??ADA???????????)??,????

(??????????? ???? ????) ???????????:???????

??

??:???????????,??????????,??????????????