??????????????

?2025??2???????????21?,??????«??????»????“Base-modified nucleotides mediate immune signaling in bacteria(??????????)”???????????????????????(?)??????,????“????????????????”(Kongming),?????????????“?????????????????????”????????????????????,????????????

????????????????????????????,????????,?????????“????”??????1950????????????(??????cAMP?cGMP)???????,?????,?????????,?????,?????????????????,??????????????????KomA(????A)?KomB(?????????B)?KomC(????????????????????C)????????????????????????????????????????????,??????(DNK)????“????”:KomA?????????????DNK??????????,??(dAMP)??????dITP????KomC?????NAD⁺,?????????“??”??????????????,???????????????????????,?????????????????“??”??????????,???????????“???????????????”??????????????,????

????,“???”??????????????????,????(??KomB-KomC??KomA)???????????????????????,?????????????????dITP????????????:???,?(??ADA???????)???,????????

(? ???? ??) ?????????????:??