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????2025??2?????????????21??????????????????,?«??»???????????“Base-modified nucleotides mediate immune signaling in bacteria(????)”????????????????????(??)???????????????????????,??“???????????”(Kongming),??????“????”?????????????????,?????????????????

?,??????,??????“??????”???????????????????1950????????????????????(?cAMP?cGMP)????????????,????????,?????????????????????????,???????????????????????,???,?????????????????KomA(??A)?KomB(??B)?KomC(????C)??????????????????????????????????????????????????????????,??????????(DNK)?“?”:KomA???DNK??,??(dAMP)??????dITP?????KomC??????????NAD⁺,????????????????????????????“???????????”?????????????,?????????,?????“???”????,??“???????”???????,???????????????????

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