??????????????????????

????:????????:???????

??7????????3?? (?? ???)???3?,???

??????????(??)????HBV????????????????????????????????(siHBV),??,??????

??????Signal Transduction and Targeted Therapy?

?????????????????,????(HBV)????????(CHB)???????,????????(RNAi)???????(HBsAg)?????

????????????????,??????(tLNP)??????????????????,????,????????????????????????????????????????????????????????,???????????RNAi???????????HBV??,???,?HBV?????????????T???????,??????????????????????????????(?????????????????????????????????????) ????????????????????:????