????:1???????:???????

2???????????

3??????????

4???95??

5????????????

?8????????????22???? (? ??)“KRAS??,???‘???’???KRAS G12C??????”?????????????????????????????????

?21??,?????,???????????????1???????????????????????(???????????:???????????????)?????,???????????(KRAS)G12C?(NSCLC)??????,?????

??,????KRAS G12C???????????,???????

??????,????????????,2022???????????,??106.1??????????,???????????????????????????????80%85%,???????????????Kirsten???(KRAS)?????????????????,??????????????????????????????????????????????????????????????????KRAS G12C?????????3%,?????2.7?????????????

??KRAS???????????“??”,??,?????????,???????????????????????????40?????????,?????????,????

????,?????????KRAS G12C????,???(??) ???????:?????????????????????????