????:1??????????:????wx

2?????????

3???????????

4?????????

5?????95?

???7??3?????? (????????????????? ??)??3????????????????,???

????(?????????)????????HBV?????????????????(siHBV),?????????????????????????????,??????????????????????????????????????

????Signal Transduction and Targeted Therapy?

???????????????????,?????????????(HBV)??(CHB)???,?????????(RNAi)?(HBsAg)???????????????????

???????????,??????????(tLNP)???????????,??????,?????????????????????????????????????????????????,???RNAi????????????????HBV???????,??,??????????HBV??T???,?????????(?????) ????????:???