????:1??????????????:?????

2???????

3??????????????

4????????????

5?????????????

?????????????????????????????????????7?????3?? (????????????????? ??)???????3??,????????????????????

???????(??????????)???HBV?????????(siHBV),?????????,????????????

?????????????????????????????????Signal Transduction and Targeted Therapy?

????,?????????????(HBV)???(CHB)???????????,??????(RNAi)????(HBsAg)???

????????,??(tLNP)???????????,??????,???????????????????????????????????????????????,?RNAi??????????HBV????????????????,?,????????HBV????T????????????????,???????????????????(???) ??????:????