�???????�????

????:???????95?:???????

?????????????2023????????????,??????????60????2.97????,??????21.1%????????,????????????1.9??,?????????????4,000????,?,�??????????????????�??????????????????

????????,?????????????,????,2024???????????

??,??????????????,????????????????????????????????????????????�2024???60??????�(????�?????�)?

�2024???60?????�????

?????????????5?�????????????????????VIP?�????????????,??????????????????????????60?????60?,????????,??,?,????,?????

?,?2023?????6?????1????2024??????????5????????????31??????????????60??604,362??,?????

�2024??????60???�??????????????????????

?,?????,?????????????????????????,????

?,?????,?????,??????????,?,????????????

60???????????????2.91�,??3/10????

??,??????????,??????,??????????????????????,2024??????60???????????:????2023??6???1??????2024?????3??????31??60?????????????516,690?,????????????????????1,503?????,???2.91�(1,503??/516,690???????)???????60??????100%??????????CT????????

?,?????????????????????????????????????529??,?????????????????????/??????????????????????????????????????????????????????????

�2024???60??�??

???????60???????????,??????,??????????????????,?????????????,????????????????

�????????????????�????,????,?????,????????????????????????529???????,??85%?????????CT?????,???10%????????????X????????????????????

�2024???????????????????????60???????�?

??????????????????????????????????60???????????CT??40%,????X??43%????????????CT????X????????????,??????????????????CT????X?????????????????????????5????,??CT????????100%,????????????????,??????60??,??100%????????????CT???60??????????????6????????????,????

5????????5?????????,60?�?????????????????????????�??????????????????

???????????,????????????????????????,?????(????)?60???,?5??3?????????,?????????????????(???????????)?????????????/?????????(??)???????????(BMI)?????????????????(??????),??5????

�2024???60????????�?????????????????????????TOP5

?????????2020?????????2024?????????60???????????,??????(??)????????????????(?)??????????????????????(????????????)??????????????????????????(????????)??????????(??????)??????????????????,????????????????(????)?????????????????(???????????)???????,?10??,60??????????????????????????????60???

??,????,????,???????????????????/??????????????????:??????60????(????????????)?10%,?????

�2024??60??????� ??(????????)??????????????

2023?????�?????2022�?:????????,?,????????????????????????????????60??????????????????????????????????,?????????

60?100%?????:60????146,843?????????,??????98%,????,???????

�2024?????60??�??

??,????????,?????80????????????????????,???????????????????????????,?????????????????????,??????????????????�?????????????????????????????�??????30-40%??????????????????????????,????,?????????????????????????????????�??????????�??

?:60??????????????????????????????????????(?????(HbA1c)????????????????(FBG)??????)???????(??????(TC)???????????(LDL-C)???????????(TG)??????)???30%-40%?????????????????????,??60?????????????????(HbA1c)????????;????(FBG)???????????????75?????79?????????????????,?????40%,???

?????????

????�?????2018??�?,???????????3??,???????????????,??????????60~70%?????????(AD)??????????????1,000?AD???????????,?????AD??????,????????????????????????????,APOEe4?AD?????,??AD??4~10??????????,????50%??AD??????????APOEe4?????????????????????

???????????????????,????????AD?????,??AD????????:????????????2023???12?,?????349???????????APOE??????????????????????APOEe4??????????????????????????????????(????????)?17.65%????????,??APOEe3e4????,?15%,?????????4.54?????????????

�2024??60???� ?APOE????

???????AD??,?????10???20?,????????????,??????????????????????????????????????

2024???,?microRNA(miRNA)?????,???????????????????????,????57????AD???????????????2024????6?,?2,000????????????????�???????3?(microRNA)??????????�,????AD??,??????????AD??????

??AD??,????????????????????,????????????,??(?????????:??????)??????AD?,?????????????AD???�????????????�?????,??????AD????????

2024????7?,?,????,???????????????,?????????????AD?????????,????????????????60???????????,?100%?????????????