????|?????????????????????

????:??95??:????????

?10??????????????????????17?(???????????)10??????17????????????????,???,?????«?????:????????????????????????????????»???????????(RT-QuIC)????????????????,?????????????????

??,????(CJD)????????(FFI)?????????Gerstmann-Str?ussler-Scheinker???????????????????????(GSS)?

?????,??????????????????,?????????????????,???????????(????????????MRI??????????????14-3-3???????)??????,??????,??????????

????????,???????RT-QuIC??,????????,??RT-QuIC???????????????????????,????RT-QuIC????,???,???????????,?RT-QuIC?????????????????

??????101?????????23??????????????????????????????????????????????????????,??????????????????94??????????????,????????????????????????????????,??????????????????????RT-QuIC?84.9%???????80.0%?????????83.7%??84.8%?

??????????,???,??92.1%,?????(75.5%)????,???95%,????????????????????(??) ??????????????????:???????????