????:1??????????:????????

2????????

3??????92?95?98?

4???????

5???????????

????8?????22??????????????? (????? ?)“KRAS??,?????????????????????‘?????????’????KRAS G12C????”???????????????????????

??21???????????????????????,???????????,??????????????1?(?????:???????????????????????????)????,?(KRAS)G12C??????????????????????????????(NSCLC)??,???????????

?????????????????,???????????????????????????????KRAS G12C?????????,?????????????????????????

?,???,2022??,??????106.1????,?????????80%85%,????????????Kirsten????(KRAS)??,????????????????????????????????????KRAS G12C??????3%,???????????2.7??????????

?????KRAS????????????“??”,??,????????????????????,??40????????????,????,???????

????????????,??KRAS G12C??,????(?????????) ????????????:????