??????????????

????:?????????:???????????

????2025??????2??????21?,????«????»??????“Base-modified nucleotides mediate immune signaling in bacteria(?????????)”????????????(???)??????,??????????“?”(Kongming),????“????”??????????,??

??????,???????????,???????????“?”???????????????????1950?????????????(??????????cAMP?cGMP)????,?????????????????????,???????????????????????????,??????,?????????????????????????????????????,????KomA(?????????????????A)?KomB(????B)?KomC(????????????C)??????,??(DNK)???????“????”:KomA????DNK???????????,???????????(dAMP)?dITP???KomC???NAD⁺,?????????????????????“????”?????????????????????????????????????,??????,??“???????”??,????????????“??????”???????????????????,???????????????????

?????????????,“?????????????????”???,??(?KomB-KomC????????????KomA)??????????????,?????????????????dITP?:??,??(??ADA????????????????)????????????????????????????,???

(?? ?? ????????????????????) ????????????????:???????????????????